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KMID : 1155220200450040410
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Journal of the Korean Society of Health Information and Health Statistics
2020 Volume.45 No. 4 p.410 ~ p.417
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Relationships between Thyroid Function and Depression and Stress in Adult Females
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Seo Min-Yi
Hyun Seung-Jae
Park Sang-Shin
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Abstract
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Objectives: The number of thyroid-related patients in Korea is steadily increasing. Women received treatment for hypothyroidism5.3 times more than men and treated for hyperthyroidism 2.5 times more than men in 2018. The purpose of this study was to find out the relationships between thyroid function and depression and stress in adult females.
Methods: This study was conducted on 2,991 adult females who participated in the 6th Korea National Health and Nutrition Examination Survey. Participants were classified as normal, hypothyroidism and hyperthyroidism according to the thyroid stimulating hormone (TSH) and free thyroxine (fT4) level. To examine the dose-response relationship, the participants were categorized by quartiles of the TSH and fT4 level and analyzed through multiple logistic regression on depression and stress.
Results: Hypothyroidism with high TSH level group had 57% lower risks for depression (odds ratio, OR = 0.43, 95% confidence interval, 95% CI = 0.19-0.95, p= 0.004). The lowest TSH quartile was 2.79 times more likely to have depression compared to the highest quartile (OR = 2.79, 95% CI = 1.32-5.92, p= 0.020). The lowest TSH quartile was 40% lower risks for stress than those in the highest TSH quartile (OR = 0.60, 95% CI = 0.45-0.80, p< 0.001).
Conclusions: We demonstrated that the relationships between thyroid function and depression and stress remain poorly defined in adult females. Further studies are required to confirm the exact cause-effect relation of this association.
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KEYWORD
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Thyroid stimulating hormone, Free thyroxine, Depression, Stress, Female
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